FGF10 and LADD syndrome: The critical role for FGFR signaling in human SGs is evident by haploinsufficiency of either FGFR2b or FGF10, which leads to two rare genetic diseases, aplasia of lacrimal and salivary glands (ALSG: MIM #180929) and lacrimo-auriculo-dento-digital syndrome (LADD: MIM #149730)13.