IL6 and Cognitive impairment: In this double-blind randomized controlled study, we used an IL-6 immunoassay, 3.0-T magnetic resonance imaging (MRI), and the MATRICS Consensus Cognitive Battery (MCCB) to investigate the associations among the IL-6 level, GMV alterations, and cognitive impairment in drug-naive patients with first-episode schizophrenia.