PPARGC1A and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Given that during stress, AMPK also activates peroxisome proliferator-activated receptor‐γ (PPARγ) co-activator 1α (PGC1α), which regulates mitochondrial biogenesis genes through interaction with PPARγ or estrogen-related receptors (ERRs)26, we next examined mitochondrial biogenesis in our ADTKD-UMOD mouse model.