MANF and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Together, these data support that MANF upregulation in ER-stressed TAL cells is indispensable for maintaining autophagic activity, and that loss of MANF in mutant TALs exacerbates autophagy inhibition and mutant UMOD accumulation, further intensifying kidney injury in ADTKD-UMOD.