Gene set enrichment analysis (GSEA) of the combined profiles of the BRAFi-resistant versus parental cell lines showed positive enrichment of an established AR-responsive gene signature (Wikipathways22: https://www.gsea-msigdb.org/gsea/msigdb/) and gene signatures previously connected with acquisition of BRAFi resistance, specifically epithelial-mesenchymal transition (EMT) and undifferentiated and neural crest melanoma cells (UNDIF and UNDIF-NC)23, as well as EGFR24 and TGF-ß signaling24 (Fig. 1f, g). This evidence concerns the gene AR and melanoma.