STAT3 and melanoma: We found that pronounced induction of AR expression occurred in a panel of primary and established melanoma cells already by 48 hours of treatment with DAB and other BRAF and MEK inhibitors (Fig. 2a), while inhibitors of other key signaling pathways, such as NF-κB, STAT3, and AP-1 exerted no such effect (Supplementary Fig. 2a).