We have recently demonstrated a key role of neuronal NOX2 in mediating Aβ metabolic and network toxicity (Malkov et al., 2021), while others have shown neuronal NOX to drive neurodegeneration in mouse PD (Belarbi et al., 2017; Keeney et al., 2022; Tu et al., 2023) and tauopathy (Luengo et al., 2022) models (see corresponding sections below for more detail). Here, CYBB is linked to Parkinson disease.