Further, their dysfunction is linked to cancer (ATP13A2-4), neurodegeneration such as Kufor-Rakeb Syndrome, a form of early-onset Parkinson’s disease with dementia (ATP13A2), cardiovascular diseases such as pulmonary arterial hypertension (ATP13A3), and neurodevelopmental disorders like schizophrenia and autism (ATP13A4) (200). Here, ATP13A2 is linked to Kufor-Rakeb syndrome.