In hypopharyngeal squamous carcinoma, a high level of OGT and O-GlcNAc enhances the stability NF-E2-related factor 2 (NRF2), which is closely associated with survival and chemoresistance of cancer cells, via activation of the PI3K/Akt pathway to drive the tumor growth (98, 99). Here, OGT is linked to neoplasm.