Importantly, the growth of intracranial tumors is impaired by OGT inhibition, which is successfully rescued by overexpressing phosphomimic ACSS2-S267D mutant, further implicating the crucial role of OGT and O-GlcNAc in promoting glioblastoma growth and survival via regulation of acetate and lipid metabolism (62). The gene discussed is OGT; the disease is glioblastoma.