A comparison of good-prognosis MPNSTs versus neurofibromas showed downregulation of several genes important in Schwann cell development, myelination, and neuron function, including CDH19, ERBB3, GAS7, NRXN1, PMP2, S100B, SCN7A, and SOX10 (fold change < −2; Supplementary Fig. S15). This evidence concerns the gene SOX10 and plexiform neurofibroma.