Notably, ERBB2 was not differentially expressed between immune deficient MPNSTs and neurofibromas (fold change −0.44, FDR-P = 0.2), and differential expression between the MPNST subtypes was caused by downregulation of the gene in immune active MPNSTs compared to neurofibromas (fold change −1.03, FDR-P = 0.006, both from limma analysis; Supplementary Fig. S11). Here, ERBB2 is linked to malignant peripheral nerve sheath tumor.