MYC and neoplasm: Gene set enrichment analysis of the Hallmark gene set collection (n = 50)37 showed downregulation of immunological processes in the malignant tumours, including interferon-α and interferon-γ response (FDR-P<1 × 10−8), and upregulation of proliferative processes, including the E2F and MYC targets and the G2M checkpoint (FDR-P<1 × 10−9, both from camera gene set test36; Supplementary Table S9).