NF1 and SUZ12 are also among the few identified targets of recurrent mutations at the nucleotide level, together with TP53 and EED (encoding another PRC2 component).14, 15, 16, 17, 18 Loss of function of PRC2 results in epigenetic deregulation by loss of trimethylation at lysine 27 of histone H3 (H3K27me3), and might be associated with malignant progression of the tumours.14 This evidence concerns the gene NF1 and neoplasm.