This included the cancer-critical genes ABI1, ARHGEF12, BIRC2, CBL, CYLD, JAK1, JAK2, KDM2A, NCOA4, PICALM, PTEN, RB1, SDHB, SDHD, and USP14 (Supplementary Fig. S12). The gene discussed is ARHGEF12; the disease is cancer.