Since the ability of malignant cells to metastasize to other sites or organs depends on their ability to pervert and exploit natural wound-healing pathways [24], hypothesizing that SSH1 plays a vital regulatory role in the circadian modulation of the cellular actin cytoskeleton and that this influences cell motility, propensity to metastasize, treatment response, and ultimately the prognosis in patients with HCC. Here, SSH1 is linked to hepatocellular carcinoma.