The slingshot family protein phosphatases (SSHs) currently compose of structurally overlapping but functionally distinct SSH1, SSH2 and SSH3 in mammals, and are reported to ‘specifically dephosphorylate and reactivate Ser-3-phosphorylated cofilin (P-cofilin)’, where upregulation of cofilin-1 has been shown to positively correlate with cancer aggression and metastasis [15]. Here, SSH1 is linked to cancer.