Furthermore, synchronous analysis of TCGA-LIHC (n = 421), TIGER-LC (n = 122), GSE14520 (n = 445), GSE25097 (n = 511), GSE39791 (n = 433), and GSE36376 (n = 133) HCC datasets demonstrated that the expression of SSH1 exhibits the satisfactory or good capability to differentiate non-tumor from tumor cases as expressed by the area under the receiver operating characteristics curves (AUCs) of 0.62 (p = 0.006), 0.72 (p < 0.0001), 0.70 (p < 0.0001), 0.67 (p < 0.0001), 0.74 (p < 0.0001), and 0.77 (p < 0.0001), respectively (Figure 2A). Here, SSH1 is linked to hepatocellular carcinoma.