In concordance, analysis of the GSE14520 HCC dataset (n = 434) found that while the median expression of SSH1, ARNTL/BMAL1, ACTB, LIMK1, GRB2, CTNNB1/β-catenin, and VIM were upregulated, CXCR4, CXCL12, GSN, BHLHE40, BHLHE41 and RORA were downregulated in liver tumor tissues (Figure 4C). This evidence concerns the gene GRB2 and hepatocellular carcinoma.