As shown in Table 1, elevated GPR37 in glioma was significantly associated with the CNS WHO grade, histological type,1p/19q codeletion, the IDH status, CDKN2A/B homozygous deletion, age and primary therapy outcome (P < 0.05), while no significant correlation was seen with gender (P > 0.05). The gene discussed is CDKN2A; the disease is central nervous system cancer.