Moreover, univariate logistic regression analysis (Table 2) showed a significant correlation of GPR37 mRNA expression with CNS WHO grade (G4 vs. G2 & G3, OR = 0.380, 95% CI (0.069–0.692), P < 0.001), histological type (Glioblastoma, IDH wildtype vs. Oligodendroglioma, IDH mutation, 1p/19q-codel vs. Astroctyoma, IDH mutation, OR = 0.397, 95% CI (0.040–0.754), P < 0.001), CDKN2A/B homozygous deletion (non-homdel vs. homdel, OR = 1.865, 95% CI (1.495–2.234), P < 0.001), age (≤60 vs. >60, OR = 1.466, 95% CI (1.095–1.836), P < 0.001). Here, GPR37 is linked to glioblastoma.