In this study, we confirmed that the abnormal expression of GPR37 is related to the increased infiltration of eosinophils, macrophages, NK CD56dim cells, NK cells, neutrophils and T cells etc. A number of growth factors and cytokines can be released by tumor associated macrophages (TAMs), which are drawn into the glioma environment, have immunological capabilities, and are able to react to the growth factors produced by cancer cells [60]. The gene discussed is GPR37; the disease is central nervous system cancer.