We found that GPR37 was positively correlated with several ICPs such as CD274, PDCD1LG2, PDCD1, CD80, CD86, CTLA4, PVR, TIGIT, CD96, CD226, HAVCR2, LGALS9, CD47, SIPRA, CD200, CD200R1, CIITA and LAG3, indicating that GPR37 is a promising immune-related gene that can influence immunotherapy response in glioma patients. The gene discussed is CD274; the disease is central nervous system cancer.