Examples include the elevation of C-reactive protein (CRP) and tumour necrosis factor (TNF)-α in head and neck cancer pain [5], CRP and interleukin (IL)-1 receptor antagonist with fatigue during radiation therapy in breast and prostate cancer patients [6], and IL-6, soluble IL-6 receptor, soluble IL-1 receptors, IL-10, CRP, and macrophage inflammatory protein (MIP)-1α reflecting symptom burden in myeloma [7]. This evidence concerns the gene CRP and head and neck cancer.