Specifically, we identify CAND1 as a negative regulator of the SCFFBXO11 complex in HCC and present results showing that the disassembly of the SCFFBXO11 complex stabilizes heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1), which enhances lipogenesis to promote HCC in vitro and in vivo. The gene discussed is CAND1; the disease is hepatocellular carcinoma.