In this work, we constructed a multifunctional nanoplatform to achieve enhanced PDT/chemotherapy synergistic tumor therapy by intelligently integrating the function of pyropheophorbide a (PPa, a photosensitizer), Chlorambucil (Cb, a DNA-damaging drug) and Olaparib (Ola, a PARP inhibitor). This evidence concerns the gene PARP1 and neoplasm.