LIQ relatively inhibited the proliferation and migration of DDP-resistant gastric cancer cells. DDP+LIQ promoted cell cycle arrest at G0/G1 by ↓ cyclin D1, cyclin A, and ↑ CDK4 and p53 and p21.DDP+LIQ induced apoptosis and autophagy.Inhibited tumor growth of xenograft mice. Here, TP53 is linked to neoplasm.