Urinary Gc-globulin has already been investigated in conditions as contrast-induced and acute heart failure-associated kidney injury, diabetic nephropathy, lupus nephritis, nephrosis syndrome, chronic kidney disease, and in gynecological diseases as well [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. This evidence concerns the gene GC and chronic kidney disease.