CASP6 and Hyperglycemia: F31 ameliorated hyperglycemia through different approaches: decreased adenosine, galactitol and glycerophosphocholine and increased arginine, proline, arachidonic acid, creatine, aspartic acid, leucine, phenylalanine and ornithine to protect kidney function; increased Caspase-3, Caspase-6 and Bax and inhibited Bcl-2 to promote apoptosis in epididymal fat; reduced mitochondrial membrane potential to induce adipocyte apoptosis