It was detected that taxifolin, rutaecarpine, kaempferol, quercetin, and luteolin were found to be potential active components for the anti-colitis activity of WMW, and it effectively decreased the level of RAGE protein to inhibit the activation of NF-κB and enhance the colonic ZO-1 expression, therefore intestinal barrier integrity in DSS-induced mice [164]. This evidence concerns the gene NFKB1 and colitis.