For this purpose, DNA from both CPP and control groups was searched for 3 SNPs of leptin and the leptin’s receptor genes that have been associated with a higher bone mineral density and extreme obesity: the G > A variant in the leptin promoter at nt-2548 (rs7799039) and two SNPs in the leptin receptor Q223R (rs1137101) or K109R (rs1137100). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.