CASP3 and colon adenocarcinoma: Experiments based on in vitro HT-29 human colon adenocarcinoma cells and in vivo chorioallantoic membrane assays showed an antitumor effect (due to increased AMPK) and apoptosis due to increased caspase-3 and poly-adenosine diphosphate-ribose polymerase, phosphorylation of p53 (Ser15)], and disruption of DNA [154].