In particular, regarding molecular abnormalities that could lead to the deregulation of signalling pathways involved in specific cell behaviour and, therefore, in the development of haematological malignancies, such as the LNK inhibitory adaptor protein encoded by the LNK/SH2B adaptor protein 3 (SH2B3) gene, which is the target of numerous genetic mutations, inherited or acquired in lymphoid leukaemia, high-resolution genome analysis using microarray and large-scale sequencing have both played a key role in the identification of many relevant acquired gene mutations [10]. The gene discussed is SH2B3; the disease is lymphoid leukemia.