Altered cytokine secretion in response to a diabetes support program (based on standard diabetes self-management education guidelines focused on reducing risk factors associated with diabetes complications) for 3 months was significantly related to modifications in the methylation/expression status of immune-related genes (i.e., FCER2, DUSP10, BCL2, and CD6) in monocytes from Native Hawaiian adults with diabetes mellitus [33]. This evidence concerns the gene FCER2 and diabetes mellitus.