The present study showed that a supplementation of 100 g/kg MCTs combined with 2.91 g/kg DHA for 8 months significantly improved the brain glucose metabolism, as well as decreased the nerve cell apoptosis and AD-related protein (Aβ, APP, BACE1, and PS1) expression levels in the cerebral cortex and hippocampus of the 11-month-old APP/PS1 mice. Here, APP is linked to Alzheimer disease.