VIP and constipation disorder: It also increased the content of SCFAs in faeces, restored the levels of MTL and VIP, and downregulated the levels of the pro-inflammatory cytokines IL-6 and IL-8 in the serum, thus repairing the inflammatory response caused by constipation, promoting peristalsis of the gastrointestinal tract, increasing the water content in faeces, and relieving constipation.