INS and type 2 diabetes mellitus: Over the last years, many recommendations [78,79,80,81] have been put forth by scientific communities to help clinicians in the prescription of the most appropriate nutritional intervention in subjects with T2DM: in fact, by promoting weight loss and ameliorating insulin sensitivity, diet and PA together can lead to improved blood glucose and blood pressure profiles, as well lipid levels, with effectiveness for CV safety [82].