AKT1 and cancer: Moreover, p-AKT, p-GSK-3β, p-FAK, and p-p38 were downregulated in a concentration-gradient manner in BxPC-3 cells, suggesting that the FAK/AKT/GSK-3β signaling pathway and the p38 mitogen-activated protein kinase signaling pathway are involved in the regulation of cancer cell growth and invasion by LRP3-S1.