ACHE and obesity due to melanocortin 4 receptor deficiency: For instance, several natural-based enzyme inhibitors, such as orlistat (pancreatic lipase inhibitor), acarbose (α-glucosidase), and galantamine (AChE inhibitor), have already been used to treat some major diseases, such as type-2-diabetes mellitus (T2DM), Alzheimer’s disease (AD), and obesity [3,4,5,6,7].