ENHO and Marchiafava-Bignami disease: In the present study, the correlation analysis in CKD patients showed that a decrease in serum adropin levels was negatively correlated with CKD-MBD biomarkers such as phosphorus and calcium while positively correlated with Vitamin D. In another clinical study, serum concentrations of adropin were found to be lowered in atrial fibrillation patients.