In the present study, the normal concentration of adropin was found to be (706.542 ± 11.32) pg/mL in the healthy group, which was found to be lower than the findings in CKD patients such as 413.208 ± 12.32 in CKD stage 1 and 2 patients, 284.682 ± 9.89 in CKD stage 3 and 4 patients, and 200.342 ± 8.37 in CKD stage 5 patients. Here, ENHO is linked to chronic kidney disease.