Although we are aware that the above-mentioned morphological parameters are not strictly specific to a mammary origin, we believe that they may have an important diagnostic utility in leading pathologists to suspect a possible primary breast tumor and to include GATA-3, ERs, PgRs and HER-2 in the immunohistochemical panel when dealing with a brain metastasis in their daily diagnostic practice [27,28,29,30,31]. Here, ERBB2 is linked to breast neoplasm.