Although MFCP patients may also suffer from abnormal systemic inflammation, current studies have shown that CRP levels and inflammation-related cytokines, interleukin-6 (IL-6), interleukin-10 (IL-10) and interleukin-17 (IL-17), in PC patients were significantly higher than those in MFCP patients, indicating different extents of systemic inflammation between PC patients and MFCP patients. Here, IL17A is linked to pachyonychia congenita.