PRAME and neoplasm: Up-regulation in the expression level of the AKAP3 (p < 0.0001), MAGEA4 (p = 0.043), PIWIL1 (p < 0.0001), and PRAME (p = 0.043) genes was found in the tumor samples, and lower levels of expression were detected in tumors for the CTAG1A (p = 0.012), CTAG1B (p = 0.013), MAGEC1 (p = 0.004), PIWIL2 (p < 0.