In a cross-sectional study of 57 CKD patients based on obstructive nephropathy, serum uromodulin was evaluated as a marker of early kidney dysfunction, measuring at 50.2 ± 26.3 ng/mL in comparison to the control group, which had a level of 78.3 ± 24.5 ng/mL (p < 0.001). This evidence concerns the gene UMOD and chronic kidney disease.