Furthermore, in contrast to other well-known prognostic factors for IgAN (eGFR, urinary protein, and hypertension), among patients in a relatively early stage of IgAN with eGFR > 60 mL/min/1.73 m2, multivariate analyses indicated that low serum uromodulin independently predicted a 30% decline in eGFR and the presence of severe histopathological changes. The gene discussed is UMOD; the disease is Hypertension.