SEMA3A and glomerular disorder: TEM analysis revealed the extensive fusion and effacement of podocyte foot processes in kidneys examined 4 h after SEMA3A injection, which were recovered at 48 h, demonstrating that excess circulating SEMA3A may cause podocyte ultrastructural abnormalities, and the permeability of the glomerular filtration barrier is transient and reversible, providing proof of the principle of excess SEMA3A and glomerular disease.