It was also reported that curcumin, well known for its antioxidant and anti-inflammatory properties, and 12/15 lipoxygenase inhibitor-LOXblock-1 ameliorated IRI-induced AKI by reducing inflammatory processes, oxidative stress and apoptosis, and the effects were through the suppression of the SEMA3A signaling pathway [91]. This evidence concerns the gene SEMA3A and acute kidney injury.