SEMA3A expression was increased after LPS-induced AKI in mouse tubular epithelial cells, as well as in an LPS-treated rat-kidney-proximal-tubular-epithelial-cell line in vitro via Rac1/nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) p65 and JNK pathways [45]. The gene discussed is SEMA3A; the disease is acute kidney injury.