Management and Outcome: The treatment of TS involves targeting several mechanisms in terms of inhibiting new thyroid hormone synthesis, inhibiting thyroid hormone release, inhibiting the peripheral effect of thyroid hormone (20% of T3 is secreted from the gland and 80% is produced by conversion of T4 to T3), inhibiting enterohepatic circulation of thyroid hormones, inhibiting deiodinases D1 and D2, blunting the adrenergic surge, and supportive, resuscitative, and circulatory support measures, plasma exchange, and surgical treatment [2]. This evidence concerns the gene TG and Timothy syndrome.