RUNX2 and Marfan syndrome: In addition, OSmfs suggests that the overexpression of lysophospholipase 1 (LYPLA1), DBF4 zinc finger B (DBF4B), matrix metallopeptidase 13 (MMP13), polo like kinase 1 (PLK1), transmembrane protein 158 (TMEM158), Wnt family member 5B (WNT5B), and RUNX family transcription factor 2 (RUNX2) may potentially predict a poor OS in MFS.