Indeed, the knock-out of the gene for GHR in the liver of mice (GHR KO mice = uncoupling of the GH-IGF-1 axis) initiates hormonal and metabolic changes [98] that resemble the lipidosis and ketosis seen in cows: increased GH and NEFA concentrations in blood, insulin resistance and low IGF-1 concentrations. Here, IGF1 is linked to lysosomal lipid storage disorder.