The prognostic value of CK17 was first established by Regenbogen et al. [13] in a cohort of 78 oral, oropharyngeal, and laryngeal HNSCC of various disease stages where CK17 status was found to predict OS based on strong (2+) staining cut-off of 85% tumor cells as determined with PathSQ score across all anatomic locations. Here, KRT17 is linked to head and neck squamous cell carcinoma.