As a DAMP, HMGB1 release by necrotic cells plays a role in priming immune cells to recognize dead or damaged tumor cells; however, this acute inflammatory effect by HMGB1 also results in sustained inflammation in the PCa microenvironment by RAGE ligand activity, ultimately promoting treatment resistance and tumor growth through RAGE activation [54,55]. The gene discussed is HMGB1; the disease is neoplasm.