Patient tumor biopsies were analyzed using IHC for Nectin-4 expression.High expression of Nectin-4 in squamous cell carcinoma and adenocarcinoma may guide treatment with novel Nectin-4-directed ADCs and provide a high-risk patient collective with a new promising therapeutic option.Nectin-4-directed therapy enfortumab vedotin, an ADC comprised of a fully human monoclonal antibody specific for nectin-4 conjugated through a cleavable linker to the microtubule inhibitor MMAE.Nectin-4 was not prognostic in histological subtypes of BC [171]. Here, NECTIN4 is linked to adenocarcinoma.