In the context of lymphoma originating from the germinal center, such as PMBL, the SOCS1 gene is indeed a known target of the mutagenic enzyme activation-induced deaminase (AID), which initiates somatic hypermutation (SHM) by converting cytosine (C) to uracil (U) in single-stranded DNA [65,66]. This evidence concerns the gene AICDA and lymphoma.