The presence of RET mutations, both together and when considering M918T alone, correlates to an advanced stage of the disease (p = 0.0025), a higher tumour (T) category (p < 0.0001), and the presence of both lymph-node (N) (p = 0.0021) and distant metastases (M) (p = 0.0073) [54]. The gene discussed is RET; the disease is neoplasm.