While BRAF (mainly BRAF V600E) is a well-known oncogenic variant involved in various cancers, such as melanoma [101] and papillary thyroid cancer [102], in sporadic MTCs, BRAF V600E has rarely been reported [73,76,77,103,104,105,106] and appears to be a distant marginal driver. The gene discussed is BRAF; the disease is thyroid gland papillary carcinoma.