RET and metastatic malignant neoplasm in the lymph nodes: In G533C MEN2A patients, Tamahana et al. showed that IVS14-126G>T was associated with a younger age at diagnosis and IVS8+82A>G (intron 8, c.1648+84G>A, rs3026750); 85–86 insC (intron 6, c.1648+88delC, rs754105711) was associated with the presence of lymph node metastases at diagnosis [133].