Among the thyroid specimens from 16 MEN2A patients (15 MTCs and 1 HCC without MTC), they found four patients with a somatic RET M918T mutation: two had germline high-risk variants, C634R and C634S, and the other two had germline moderate-risk variants, C618R and 620R. The gene discussed is RET; the disease is medullary thyroid gland carcinoma.