Le et al. [146] designed docetaxel-loaded pegylated poly(D, L-lactide-co-glycolide) NPs conjugated with anti-HER2 single-chain antibodies (scFv–Doc–PLGA–PEG) and evaluated the cellular uptake and cytotoxic effect of scFv–Doc–PLGA–PEG on a 3D tumor spheroid model of BT474 (HER2-overexpressing) and HCT116 (HER2-underexpressing) cancer cells. Here, ERBB2 is linked to neoplasm.