Severe (mostly grade 3) toxicities occurred in 29 (85%) of the 34 patients, including myelosuppression—either anemia, or low neutrophil or platelet count—(n = 24); hypotension (n = 6); pain (n = 6); hypertension (n = 3); bronchospasm (n = 2); urticaria (n = 1); anorexia (n = 2); diarrhea (n = 3); skin ulceration (n = 1); vomiting (n = 1); laryngeal edema (n = 1); serum sickness (n = 1); a grade 4 increase in alanine aminotransferase and aspartate aminotransferase levels (n = 1); and febrile neutropenia (n = 1). The gene discussed is GPT; the disease is urticaria.