AXL and neoplasm: The AXL/Gas6 (Growth Arrest Specific 6) signaling pathway plays a role in tumor cell proliferation, and plasma detection of the AXL soluble form, obtained by an ADAM10/ADAM17 (ADAM Metallopeptidase Domain)-specific shedding mechanism, has been described as an early signature of PDAC [69], while its functions, likely relying on attenuating Gas6 functions in the TME, remain unknown [70].