NFKB1 and colorectal carcinoma: These phenomena are likely due to a reduced colonic butyrate, a fiber fermentation product of colon bacteria that suppresses colonic NF-κB activity inflammatory cytokines and can modulate Wnt signaling, the most activated pathway in CRC [44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62].