Consistent with this notion, the mouse homologous genes of human PRDX6, MAGOHB, NUCKS1, DCAF13, and TXN were upregulated by taxifolin in LL2 LC tumors (Table S2A) and facilitated CTL-derived toxicity towards cancer cells (Figure S4A). The gene discussed is NUCKS1; the disease is laryngotracheoesophageal cleft.