In both TCGA LUAD and LUSC cohorts, ITGAL, ITGAX, and TMEM119 expressions were robustly correlated with tumor-associated myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and macrophages, along with the expression of multiple immune checkpoints; these correlations were also detected in a panel of human cancers. This evidence concerns the gene ITGAL and cancer.