VSIR and cancer: The robust and positive correlations of ITGAL, ITGAX, and TMEM119 with numerous immune checkpoints, including TIGIT, CD96, PDCD1 (encoding PD-1), CTLA4, LAG3, CD274 (PD-L1), VISTA, ICOS, BTLA, and others, as well as a set of immune cells including MDSC, Treg, and macrophages in NSCLC (Figure 4 and Figure 5B,C) and across human cancer types (Figures S5 and S7) strongly suggest the general immunosuppressive actions of ITGAL, ITGAX, and TMEM119 in NSCLC and human cancers.