On the other hand, Itgal, Itgax, and Tmem119 in LL2 tumors were downregulated by taxifolin; their human counterparts (ITGAL, ITGAX, and TMEM119) displayed positive T cell dysfunction values (Figure 3A), suggesting their negative impact on CTL-derived cytotoxicity in tumor cells [45]. This evidence concerns the gene TMEM119 and neoplasm.