The robust and positive correlations of ITGAL, ITGAX, and TMEM119 with numerous immune checkpoints, including TIGIT, CD96, PDCD1 (encoding PD-1), CTLA4, LAG3, CD274 (PD-L1), VISTA, ICOS, BTLA, and others, as well as a set of immune cells including MDSC, Treg, and macrophages in NSCLC (Figure 4 and Figure 5B,C) and across human cancer types (Figures S5 and S7) strongly suggest the general immunosuppressive actions of ITGAL, ITGAX, and TMEM119 in NSCLC and human cancers. The gene discussed is ICOS; the disease is non-small cell lung carcinoma.