TP53 and acute myeloid leukemia: Rather, TP53 mutations commonly co-occur with cytogenetic abnormalities, including deletion of chromosomes 5, 7, and 17 or complex abnormalities of >3 [53,54].The leukemogenesis mechanism in TP53-mutated AML might involve multiple hits accelerated by a deficient DNA repair mechanism resulting from TP53 mutation rather than epigenetic dysregulation due to DTA mutations.