Several tumor suppressor miRNAs, including several let-7 family members, miR-423, and miR-103a, were downregulated in MDS samples with SF3B1, SRSF2, and U2AF1 (U2AF35) mutations compared to wild type samples, indicating their role in MDS development [47]. The gene discussed is U2AF1; the disease is myelodysplastic syndrome.