Glioblastoma (GBM), classified as CNS WHO grade 4, constitutes adult isocitrate dehydrogenase (IDH)-wild-type diffuse astrocytic glioma and is characterized by microvascular proliferation and/or necrosis, mutation of telomerase reverse transcriptase (TERT) promotor, amplification of epidermal growth factor receptor (EGFR) gene, or changes in +7/–10 chromosome copy number [1]. The gene discussed is TERT; the disease is glioblastoma.