KLF4 and neuroblastoma: In neuroblastoma tumors, low expression of KLF4 has been associated with poor survival of patients, while its overexpression in neuroblastoma cell line SH-SY-5Y was shown to inhibit cell proliferation and induce cell arrest by upregulating the cell cycle-inhibitor p21Waf1/Cip1 as well as activating cell differentiation [104].