Although detailed mechanistic studies on the role of BCL6 expression in neuroblastoma are missing, it can be speculated that, analogous to lymphomas, BCL6 can mediate the arrest of neural crest cell differentiation involved in tumor development, as well as potentially contribute to the genetic instability observed in neuroblastomas, possibly due to attenuation of the DNA damage response [32]. Here, BCL6 is linked to lymphoma.