3.3. MCL-1 Inhibitor, S63845 Induces Apoptotic Signaling Assessed as an Accumulation of Annexin V-Positive Cells, Caspase-3/-7 Activation and Phosphorylation of Histone 2AX (γ-H2AX) with Efficiency Dependent on Melanoma Cell Phenotype. Here, CASP3 is linked to melanoma.